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Isomers of Entecavir API 恩替卡韦异构体的开发
Add time :2010-6-13 Views:3068

   Since this year, many domestic customers' Declaration and Approval of Entecavir Preparation were hindered, so they pay more attention on the R&D of the isomers of Entecavir API to further explain how to keep the mass stability of Entecavir preparation. In the meantime, many abroad customers are also studying the microimpuritites and isomers of Entecavir API with the same aim.

 

  For the past month , our technologists have thoroughly studied and produced the isomers and microimpurity of Entecavir API.

 

   Below are the 7 kinds of isomers of Entecavir API:

 

Isomer 1:(1r,3s,4r) 
Isomer 2:(1s,3s,4r) 
Isomer 3:(1r,3r,4s)
Isomer 4:(1s,3r,4r)
Isomer 5:(1r,3s,4s)
Isomer 6:(1s,3s,4s) 
Isomer 7:(1r,3r,4r)  

 

     Now we have produced Isomer 1,2,4,7, and ascertained their structure. Their assay is all above 98%. The balance isomers are estimated to be completed before August this year. Besides, we have extracted two impurities sample of Entecavir API, and made preliminary explanation.

   

      Welcome home and abroad customers who are interested in the isomers and impurities of Entecavir API to contact us.